DP308 | 53BP1 inhibitor | Probechem Biochemicals

Chemical Structure : DP308

DP308 (DP 308)

Catalog No.: PC-21491Not For Human Use, Lab Use Only.

DP308 is a novel and effective 53BP1 tandem Tudor domain (TTD) inhibitor, disrupts the binding between 53BP1 and H4K20me2 peptide with IC50 of 1.69 uM.

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Biological Activity

DP308 is a novel and effective 53BP1 tandem Tudor domain (TTD) inhibitor, disrupts the binding between 53BP1 and H4K20me2 peptide with IC50 of 1.69 uM.
DP308 directly binds to 53BP1-TTD protein with binding affinity (Kd) of about 2.7 μM in SPR assays.

Physicochemical Properties

M.Wt	349.43
Formula	C21H23N3O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-N-(2-(diethylamino)-4-methylquinolin-6-yl)-3-(furan-2-yl)acrylamide

References

1. Yanli Sun, et al. Bioorg Med Chem. 2021 Mar 15:34:116054.

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DP308 (DP 308)

Biological Activity

Physicochemical Properties

References

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