Chemical Structure : GSK343
CAS No.:
1346704-33-3
GSK343
(GSK 343, GSK-343)
Catalog No. : PC-21950Not For Human Use, Lab Use Only.
GSK343 is a highly potent, selective, SAM-competitive, and cell-active EZH2 inhibitor with IC50 of 4 nM and Kiapp of 1.2 nM.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-2195001
Biological Activity
GSK343 is a highly potent, selective, SAM-competitive, and cell-active EZH2 inhibitor with IC50 of 4 nM and Kiapp of 1.2 nM.
Physicochemical Properties
M.Wt
541.70
Formula
C31H39N7O2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
1-Isopropyl-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-6-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-indazole-4-carboxamide
References
1. Verma SK, et al. ACS Med Chem Lett.
2. Amatangelo MD, et al. Cell Cycle
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