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Chemical Structure : GSK343
CAS No.: 1346704-33-3
Catalog No.: PC-21950Not For Human Use, Lab Use Only.
GSK343 is a highly potent, selective, SAM-competitive, and cell-active EZH2 inhibitor with IC50 of 4 nM and Kiapp of 1.2 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $138 | In stock | |
| 50 mg | $218 | In stock | |
| 100 mg | Get quote | ||
| 200 mg | Get quote |
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GSK343 is a highly potent, selective, SAM-competitive, and cell-active EZH2 inhibitor with IC50 of 4 nM and Kiapp of 1.2 nM.
GSK343 displays 60-fold selectivity over EZH1, and >1000-fold over other methyltransferases.
GSK343 potently inhibits H3K27me3 in HCC1806 breast cancer cells with IC50 of 174 nM.
| M.Wt | 541.70 | |
| Formula | C31H39N7O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-Isopropyl-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-6-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-indazole-4-carboxamide |
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1. Verma SK, et al. ACS Med Chem Lett. 2012 Oct 19;3(12):1091-6.
2. Amatangelo MD, et al. Cell Cycle. 2013 Jul 1;12(13):2113-9.
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