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EPZ-030456

Chemical Structure : EPZ-030456

CAS No.: 1808011-23-5

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EPZ-030456 (EPZ 030456;EPZ030456)

Catalog No.: PC-70107Not For Human Use, Lab Use Only.

EPZ-030456 (EPZ030456) is a potent, selective SMYD3 inhibitor with biochem IC50 of 4 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    EPZ-030456 (EPZ030456) is a potent, selective SMYD3 inhibitor with biochem IC50 of 4 nM; displays noncompetitive inhibition with respect to SAM and MEKK2 with Ki of 1.2 and 1.1 nM, respectively; has cellular potency (IC50=48 nM) suitable to probe the in vitro biology of SMYD3 inhibition.

    Physicochemical Properties

    M.Wt 572.121
    Formula C28H34ClN5O4S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-((1R,3r,5S)-8-((4-(benzylamino)piperidin-1-yl)sulfonyl)-8-azabicyclo[3.2.1]octan-3-yl)-6-chloro-2-oxoindoline-5-carboxamide

    References

    1. Mitchell LH, et al. ACS Med Chem Lett. 2015 Aug 27;7(2):134-8.

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