MS-453 |Cas:2059892-29-2 Buy MS-453 from ProbeChem, Global Biochemicals Supplier

Chemical Structure : MS-453

Catalog No.: PC-60300Not For Human Use, Lab Use Only.

MS-453 (MS453) is a potent, selective and covalent protein lysine methyltransferase SETD8 inhibitor with IC50 of 804 nM.

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Biological Activity

MS-453 (MS453) is a potent, selective and covalent protein lysine methyltransferase SETD8 inhibitor with IC50 of 804 nM.

MS-453 exhibits selectivity for SETD8 against 28 other methyltransferases.

MS-453 does not causes significant reduction in the H4K20me in HeLa cells at up to 10 uM.

MS-453 shows poor membrane permeability (4.4 nm/s) and high efflux ratio (137).

M.Wt	385.468
Formula	C20H27N5O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-((6,7-dimethoxy-2-(pyrrolidin-1-yl)quinazolin-4-yl)amino)propyl)acrylamide

1. Butler KV, et al. J Med Chem. 2016 Nov 10;59(21):9881-9889.