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MS023

Chemical Structure : MS023

CAS No.: 1831110-54-3

MS023 (MS-023, MS 023)

Catalog No.: PC-45658Not For Human Use, Lab Use Only.

MS023 is a potent, selective, and cell-active inhibitor of type I PRMTs with IC50s of 30/119/83/4/5 nM for PRMT1/3/4/6/8 respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

MS023 is a potent, selective, and cell-active inhibitor of type I PRMTs with IC50s of 30/119/83/4/5 nM for PRMT1/3/4/6/8 respectively.
MS023 does not inhibit PRMT5/9/7(>10 uM).
MS023 inhibits H4R3me2a and H3R2me2a levels in MCF7 cells.

Physicochemical Properties

M.Wt 287.3999
Formula C17H25N3O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 30 mg/mL

Chemical Name/SMILES

1,2-Ethanediamine, N1-methyl-N1-[[4-[4-(1-methylethoxy)phenyl]-1H-pyrrol-3-yl]methyl]-

References

1. Eram MS, et al. ACS Chem Biol. 2016 Mar 18;11(3):772-81.

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