MIV-6R |CAS:1560968-55-9 Probechem Biochemicals

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Chemical Structure : MIV-6R

MIV-6R (menin-MLL inhibitor)

Catalog No.: PC-70002Not For Human Use, Lab Use Only.

MIV-6R is a potent, ligand-efficient, and cell-active inhibitor menin-MLL interaction with IC50 of 56 nM, Kd of 85 nM.

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Biological Activity

MIV-6R is a potent, ligand-efficient, and cell-active inhibitor menin-MLL interaction with IC50 of 56 nM, Kd of 85 nM.
MIV-6R demonstrateds strong and selective effects in MLL leukemia cells, and induces more pronounced increase in CD11b expression in MLL-AF9 BMCs.

Physicochemical Properties

M.Wt	417.5863
Formula	C27H35N3O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-4-(3-(4-(amino(cyclopentyl)(phenyl)methyl)piperidin-1-yl)propoxy)benzonitrile

References

1. Arkin MR, et al. Chem Biol. 2014 Sep 18;21(9):1102-14.

2. He S, et al. J Med Chem. 2014 Feb 27;57(4):1543-56.

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MIV-6R (menin-MLL inhibitor)

Biological Activity

Physicochemical Properties

References

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