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Chemical Structure : MI-463
CAS No.: 1628317-18-9
Catalog No.: PC-45726Not For Human Use, Lab Use Only.
MI-463 is a highly potent and orally bioavailable small-molecule inhibitor of menin-MLL (IC50=15.3 nM, Kd=9.9 nM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $148 | In stock | |
| 10 mg | $218 | In stock | |
| 25 mg | $378 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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MI-463 is a highly potent and orally bioavailable small-molecule inhibitor of menin-MLL (IC50=15.3 nM, Kd=9.9 nM).
MI-463 shows profound effects in MLL leukemia cells and substantial survival benefit in mouse models of MLL leukemia.
| M.Wt | 484.5398 | |
| Formula | C24H23F3N6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1H-Indole-2-carbonitrile, 4-methyl-5-[[4-[[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]-1-piperidinyl]methyl]- |
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1. Borkin D, et al. Cancer Cell. 2015 Apr 13;27(4):589-602.
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