MI-463 |CAS:1628317-18-9 Probechem Biochemicals

Chemical Structure : MI-463

CAS No.: 1628317-18-9

MI-463 (MI463;MI 463)

Catalog No.: PC-45726Not For Human Use, Lab Use Only.

MI-463 is a highly potent and orally bioavailable small-molecule inhibitor of menin-MLL (IC50=15.3 nM, Kd=9.9 nM).

Packing	Price	Stock
5 mg	$148	In stock
10 mg	$218	In stock
25 mg	$378	In stock
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Biological Activity

MI-463 is a highly potent and orally bioavailable small-molecule inhibitor of menin-MLL (IC50=15.3 nM, Kd=9.9 nM).
MI-463 shows profound effects in MLL leukemia cells and substantial survival benefit in mouse models of MLL leukemia.

Physicochemical Properties

M.Wt	484.5398
Formula	C24H23F3N6S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1H-Indole-2-carbonitrile, 4-methyl-5-[[4-[[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]-1-piperidinyl]methyl]-

References

1. Borkin D, et al. Cancer Cell. 2015 Apr 13;27(4):589-602.

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MI-463 (MI463;MI 463)

Biological Activity

Physicochemical Properties

References

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