DDD1060606

Chemical Structure : DDD1060606

Catalog No.: PC-23956Not For Human Use, Lab Use Only.

DDD1060606 is a small molecule inhibitor o fHsRNMT (RNA guanine-7 methyltransferase)-RAM (RNA guanine-N7 methyltransferase activating subunit) complex, binds competitively with cap and binds effectively to HsRNMT-RAM in the presence of the co-product SAM wth Kd of 1.6 uM.

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Biological Activity

DDD1060606 is a small molecule inhibitor of HsRNMT (RNA guanine-7 methyltransferase)-RAM (RNA guanine-N7 methyltransferase activating subunit) complex, binds competitively with cap and binds effectively to HsRNMT-RAM in the presence of the co-product SAM wth Kd of 1.6 uM.

Physicochemical Properties

M.Wt	326.42
Formula	C17H18N4OS
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(3-(1H-pyrazolo[3,4-b]pyridin-3-yl)piperidin-1-yl)-2-(thiophen-3-yl)ethan-1-one

References

1. Pearson LA, et al. Biochem J. 2025 Jan 27:BCJ20240608.

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DDD1060606

Biological Activity

Physicochemical Properties

References

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