DDD1870799 | HsRNMT-RAM inhibitor | Probechem Biochemicals

Chemical Structure : DDD1870799

DDD1870799 (DDD 1870799)

Catalog No.: PC-23957Not For Human Use, Lab Use Only.

DDD1870799 is a small molecule inhibitor of HsRNMT (RNA guanine-7 methyltransferase)-RAM (RNA guanine-N7 methyltransferase activating subunit) complex, binds competitively with cap and binds effectively to HsRNMT-RAM in the presence of the co-product SAM wth Kd of 2.5 uM.

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Biological Activity

DDD1870799 is a small molecule inhibitor of HsRNMT (RNA guanine-7 methyltransferase)-RAM (RNA guanine-N7 methyltransferase activating subunit) complex, binds competitively with cap and binds effectively to HsRNMT-RAM in the presence of the co-product SAM wth Kd of 2.5 uM.

Physicochemical Properties

M.Wt	354.39
Formula	C19H19FN4O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-fluorophenyl)-1-(3-(6-hydroxy-1H-pyrazolo[3,4-b]pyridin-3-yl)piperidin-1-yl)ethan-1-one

References

1. Pearson LA, et al. Biochem J. 2025 Jan 27:BCJ20240608.

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DDD1870799 (DDD 1870799)

Biological Activity

Physicochemical Properties

References

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