YTHDF2 Inhibitor CK-75

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Chemical Structure : YTHDF2 Inhibitor CK-75

Catalog No.: PC-24105Not For Human Use, Lab Use Only.

YTHDF2 Inhibitor CK-75 is a specific small molecule inhibitor of YTHDF2, potentially binds to a small hydrophobic pocket on the YTH domain (KD=26.2 uM), potently inhibits the protein-RNA interaction of YTHDF2.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

YTHDF2 inhibitor CK-75 is a specific small molecule inhibitor of YTHDF2, potentially binds to a small hydrophobic pocket on the YTH domain (KD=26.2 uM), potently inhibits the protein-RNA interaction of YTHDF2.
CK-75 is inactive against the YTH domains of YTHDF1, YTHDF3, YTHDC1, and YTHDC2.
CK-75 induced cell cycle changes in K562 with increased arrest at the G0/G1 phase, induced apoptosis and inhibited colony formation, and showed moderate inhibitory activity against cell proliferation.

Physicochemical Properties

M.Wt	358.35
Formula	C21H14N2O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(4-(2-hydroxy-1-naphthoyl)-1H-pyrazol-1-yl)benzoic acid

References

1. Qiu X, et al. JACS Au. 2025 Feb 10;5(2):618-630.

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