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Chemical Structure : MS152
Catalog No.: PC-22432Not For Human Use, Lab Use Only.
MS152 is a potent, selective and brain penetrant EHMT2/G9a inhibitor with biochemical IC50 of 126 nM/76 nM, respectively.
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MS152 is a potent, selective and brain penetrant EHMT2/G9a inhibitor with biochemical IC50 of 126 nM/76 nM, respectively.
MS152 dose-dependently reduced H3K9me2 levels at 48 hours in K562 cell line with EC50 of 60 nM, 5-fold more potent than UNC0642 (EC50=294 nM).
MS152 displayed excellent selectivity against 21 PKMTs and protein arginine methyltransferases (PRMTs), with no significant inhibition at 1 uM.
MS152 can efficiently reactivate the expression of paternally expressed genes from the maternal chromosome in PWS patient-derived fibroblasts.
MS152 is capable of reactivating the expression of maternal Snrpn-EGFP in mice.
MS152 treatment ameliorated the growth retardation and perinatal lethality in the PWS mouse model.
| M.Wt | 385.51 | |
| Formula | C22H31N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wang SE, et al. Mol Ther. 2024 May 24:S1525-0016(24)00336-8.
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