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Chemical Structure : MS8535
Catalog No.: PC-22053Not For Human Use, Lab Use Only.
MS8535 is a potent, selective and cell-active inhibitor of methyl-lysine reader protein SPIN1 with biochemical IC50 of 202 nM and ITC binding Kd of 30 nM.
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MS8535 is a potent, selective and cell-active inhibitor of methyl-lysine reader protein SPIN1 with biochemical IC50 of 202 nM and ITC binding Kd of 30 nM.
MS8535 displays high selectivity for SPIN1 over 38 epigenetic targets, including G9a/GLP, and >18-fold selective for SPIN1 over several other SPIN family members, such as SPIN2B (Kd = 0.56 μM), SPIN3 (Kd = 1.4 μM), and SPIN4 (Kd = 0.71 μM).
MS8535 concentration dependently blocks the interactions between SPIN1 and histone H3 in U2OS cells with EC50 of 1.1 uM in NanoBRET assay.
| M.Wt | 490.65 | |
| Formula | C28H38N6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yan Xiong, et al. J Med Chem. 2024 Mar 27. doi: 10.1021/acs.jmedchem.4c00121.
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