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TNG462

Chemical Structure : TNG462

CAS No.: 2760483-96-1

TNG462 (TNG-462 )

Catalog No.: PC-22134Not For Human Use, Lab Use Only.

TNG462 (TNG-462) is a potent, selective, MTA-cooperative PRMT5 inhibitor, selective inhibits MTAP-deleted cancer cell lines.

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Biological Activity

TNG462 (TNG-462) is a potent, selective, MTA-cooperative PRMT5 inhibitor, selective inhibits MTAP-deleted cancer cell lines.
TNG462 shows antiproliferative activity is selective for MTAP-deleted cells in vitro.
TNG462 is 45X selective for MTAP-deleted cancer cell lines over isogenic MTAP WT cell lines and has marked selectivity for MTAP-deleted cancer cell lines independent of lineage in a large, diverse cell line panel.
Oral administration of TNG462 drives dose-dependent antitumor activity including durable tumor regressions and complete responses in cell line- and patient-derived xenograft models representative of clinically relevant histologies.

Physicochemical Properties

M.Wt 520.70
Formula C28H36N6O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(6-amino-5-ethylpyridin-3-yl)-2-[(2R,5S)-5-methyl-2-[2-(1-methylpiperidin-4-yl)-1,3-benzothiazol-5-yl]piperidin-1-yl]-2-oxoacetamide

References

1. Kimberly J. Briggs, et al. Cancer Res (2023) 83 (7_Supplement): 4970.

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