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Chemical Structure : TNG462
CAS No.: 2760483-96-1
Catalog No.: PC-22134Not For Human Use, Lab Use Only.
TNG462 (TNG-462) is a potent, selective, MTA-cooperative PRMT5 inhibitor, selective inhibits MTAP-deleted cancer cell lines.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $328 | In stock | |
| 5 mg | $528 | In stock | |
| 10 mg | $858 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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TNG462 (TNG-462) is a potent, selective, MTA-cooperative PRMT5 inhibitor, selective inhibits MTAP-deleted cancer cell lines.
TNG462 shows antiproliferative activity is selective for MTAP-deleted cells in vitro.
TNG462 is 45X selective for MTAP-deleted cancer cell lines over isogenic MTAP WT cell lines and has marked selectivity for MTAP-deleted cancer cell lines independent of lineage in a large, diverse cell line panel.
Oral administration of TNG462 drives dose-dependent antitumor activity including durable tumor regressions and complete responses in cell line- and patient-derived xenograft models representative of clinically relevant histologies.
| M.Wt | 520.70 | |
| Formula | C28H36N6O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(6-amino-5-ethylpyridin-3-yl)-2-[(2R,5S)-5-methyl-2-[2-(1-methylpiperidin-4-yl)-1,3-benzothiazol-5-yl]piperidin-1-yl]-2-oxoacetamide |
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1. Kimberly J. Briggs, et al. Cancer Res (2023) 83 (7_Supplement): 4970.
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