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Chemical Structure : DC-Y13-27
CAS No.:
Catalog No.: PC-22471Not For Human Use, Lab Use Only.
DC-Y13-27 is a specific inhibitor of N6-methyladenosine (m6A) reader YTHDF2, inhibits YTHDF2 binding to m6A-containing RNA with IC50 of 21.8 uM, directly binds to YTHDF2 with a binding constant (KD) of 37.9 uM in MST assay.
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|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $238 | In stock | |
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DC-Y13-27 is a specific inhibitor of N6-methyladenosine (m6A) reader YTHDF2, inhibits YTHDF2 binding to m6A-containing RNA with IC50 of 21.8 uM, directly binds to YTHDF2 with a binding constant (KD) of 37.9 uM in MST assay.
DC-Y13-27 display no activity against YTHDF1 (IC50=165.2 uM).
DC-Y13-27 enhances responses to radiotherapy and immunotherapy in a manner similar to the deletion of YTHDF2.
| M.Wt | 270.31 | |
| Formula | C14H10N2O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(E)-2-cyano-3-(5-(3-hydroxyphenyl)thiophen-2-yl)acrylamide |
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1. Wang L, et al. Cancer Cell. 2023 Jul 10;41(7):1294-1308.e8.
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