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OTS193320

Chemical Structure : OTS193320

CAS No.: 2093401-33-1

OTS193320 (OTS-193320;OTS 193320)

Catalog No.: PC-35633Not For Human Use, Lab Use Only.

OTS193320 (OTS-193320) is a potent inhibitor of protein methyltransferase SUV39H2 with IC50 of 22.2 nM.

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Biological Activity

OTS193320 (OTS-193320) is a potent inhibitor of protein methyltransferase SUV39H2 with IC50 of 22.2 nM.
OTS193320 significantly reduces global H3K9 tri-methylation (H3K9me3) in breast cancer cells in vitro and induces apoptotic cell death.
OTS193320 attenuates γ-H2AX levels in combination with doxorubicin compared with the DOX treatment alone, and causes a significant reduction in breast cancer cell viability when compared to the treatment with a single agent.
OTS193320 causes growth suppressive effect of SUV39H2-positive A549 lung cancer cells with IC50 of 0.38 uM.

Physicochemical Properties

M.Wt 536.029
Formula C28H30ClN5O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(1s,4s)-N1-(2-(5-chloro-2,4-dimethoxyphenyl)imidazo[1,2-a]pyridin-7-yl)-N4-(4-nitrobenzyl)cyclohexane-1,4-diamine

References

1. Vougiouklakis T, et al. Oncotarget. 2018 Aug 7;9(61):31820-31831.

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