Catalog No.: PC-44245Not For Human Use, Lab Use Only.
AZ505 (AZ-505, AZ 505) is a potent and selective inhibitor of protein lysine methyltransferase SMYD2 with IC50 of 0.12 uM, displays >600-fold against other histone methyltransferases, such as SMYD3 and EZH2.
AZ505 (AZ-505, AZ 505) is a potent and selective inhibitor of protein lysine methyltransferase SMYD2 with IC50 of 0.12 uM, displays >600-fold against other histone methyltransferases, such as SMYD3 and EZH2.
AZ505 suppresses BMP2-induced SMAD1/5 phosphorylation, delays cyst growth in both early- and later-stage Pkd1 conditional knockout mouse models.
AZ505 also significantly reduced tumor growth in vivo in triple-negative breast cancer (TNBC) models.
