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Chemical Structure : AZ505
CAS No.: 1035227-43-0
Catalog No.: PC-44245Not For Human Use, Lab Use Only.
AZ505 (AZ-505, AZ 505) is a potent and selective inhibitor of protein lysine methyltransferase SMYD2 with IC50 of 0.12 uM, displays >600-fold against other histone methyltransferases, such as SMYD3 and EZH2.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $188 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $498 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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AZ505 (AZ-505, AZ 505) is a potent and selective inhibitor of protein lysine methyltransferase SMYD2 with IC50 of 0.12 uM, displays >600-fold against other histone methyltransferases, such as SMYD3 and EZH2.
AZ505 suppresses BMP2-induced SMAD1/5 phosphorylation, delays cyst growth in both early- and later-stage Pkd1 conditional knockout mouse models.
AZ505 also significantly reduced tumor growth in vivo in triple-negative breast cancer (TNBC) models.
| M.Wt | 577.5424 | |
| Formula | C29H38Cl2N4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Propanamide, N-cyclohexyl-3-[[2-(3,4-dichlorophenyl)ethyl]amino]-N-[2-[[2-(3,4-dihydro-5-hydroxy-3-oxo-2H-1,4-benzoxazin-8-yl)ethyl]amino]ethyl]- |
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1. Ferguson AD, et al. Structure. 2011 Sep 7;19(9):1262-73.
2. Gao S, et al. J Biol Chem. 2017 Jul 28;292(30):12702-12712.
3. Li LX, et al. J Clin Invest. 2017 Jun 30;127(7):2751-2764.
4. Li LX, et al. Cell Death Dis. 2018 Feb 27;9(3):326.
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