LEM-14 | NSD2 inhibitor | Probechem Biochemicals

Chemical Structure : LEM-14

CAS No.: 1814881-70-3

LEM-14 (NSD2 inhibitor LEM14)

Catalog No.: PC-35849Not For Human Use, Lab Use Only.

LEM-14 is a specific inhibitor of histone lysine methyltransferase NSD2 (MMSET/WHSC1) with in vitro IC50 of 132 uM, and that is inactive against the closely related NSD1 and NSD3.

Packing	Price	Stock
5 mg	$168	In stock
10 mg	$288	In stock
25 mg	$488	In stock
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Biological Activity

LEM-14 is a specific inhibitor of histone lysine methyltransferase NSD2 (MMSET/WHSC1) with in vitro IC50 of 132 uM, and that is inactive against the closely related NSD1 and NSD3.

Physicochemical Properties

M.Wt	478.567
Formula	C25H26N4O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-2-((4-(1-oxoisochromane-3-carbonyl)piperazin-1-yl)methyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one

References

1. Shen Y, et al. Biochem Biophys Res Commun. 2018 Nov 21. pii: S0006-291X(18)32443-4.

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LEM-14 (NSD2 inhibitor LEM14)

Biological Activity

Physicochemical Properties

References

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