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VinSpinIn

Chemical Structure : VinSpinIn

CAS No.: 2380021-98-5

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VinSpinIn

Catalog No.: PC-35846Not For Human Use, Lab Use Only.

VinSpinIn is a potent, cell active chemical probe for the Spin family protein with Kd of 10-130 nM for across the family, displays >300-fold selectivity over a panel of methyltransferases.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    VinSpinIn is a potent, cell active chemical probe for the Spin family protein with Kd of 10-130 nM for across the family (SPIN1, Kd=9.9 nM), displays >300-fold selectivity over a panel of methyltransferases.
    VinSpinIn demonstrates dose dependant inhibition of the Spin1-H3 interaction in a NanoBRET cellular target engagement assay.

    Physicochemical Properties

    M.Wt 738.978
    Formula C42H58N8O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(4-(2-((2-(3-((2-amino-5-(cyclopropylmethoxy)-3,3-dimethyl-3H-indol-6-yl)oxy)propyl)isoindolin-5-yl)oxy)ethyl)-1H-1,2,3-triazol-1-yl)-1-(4-(2-(pyrrolidin-1-yl)ethyl)piperidin-1-yl)ethan-1-one

    References

    1 Fagan V, et al. J Med Chem. 2019 Oct 24;62(20):9008-9025.

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