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OTS186935

Chemical Structure : OTS186935

CAS No.: 2093400-18-9

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OTS186935 (OTS-186935;OTS 186935)

Catalog No.: PC-35634Not For Human Use, Lab Use Only.

OTS186935 (OTS-186935) is a potent, in vivo-active inhibitor of protein methyltransferase SUV39H2 with IC50 of 6.49 nM, inhibits A549 cell growth with IC50 of 0.67 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    OTS186935 (OTS-186935) is a potent, in vivo-active inhibitor of protein methyltransferase SUV39H2 with IC50 of 6.49 nM, inhibits A549 cell growth with IC50 of 0.67 uM.
    OTS186935 causes a significant growth inhibitory effect in mouse xenograft models using MDA-MB-231 breast cancer cells as well as A549 lung cancer cells, at 25 mg/kg once daily for 14 days yielded a TGI of 60.8%.
    OTS186935 attenuates the levels of H3K9me3 in A549 xenograft mouse model.

    Physicochemical Properties

    M.Wt 463.966
    Formula C25H26ClN5O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-1-(2-(5-chloro-2,4-dimethoxyphenyl)imidazo[1,2-a]pyridin-7-yl)-N-(pyridin-4-ylmethyl)pyrrolidin-3-amine

    References

    1. Vougiouklakis T, et al. Oncotarget. 2018 Aug 7;9(61):31820-31831.

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