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Chemical Structure : OTS186935
Catalog No.: PC-35634Not For Human Use, Lab Use Only.
OTS186935 (OTS-186935) is a potent, in vivo-active inhibitor of protein methyltransferase SUV39H2 with IC50 of 6.49 nM, inhibits A549 cell growth with IC50 of 0.67 uM.
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OTS186935 (OTS-186935) is a potent, in vivo-active inhibitor of protein methyltransferase SUV39H2 with IC50 of 6.49 nM, inhibits A549 cell growth with IC50 of 0.67 uM.
OTS186935 causes a significant growth inhibitory effect in mouse xenograft models using MDA-MB-231 breast cancer cells as well as A549 lung cancer cells, at 25 mg/kg once daily for 14 days yielded a TGI of 60.8%.
OTS186935 attenuates the levels of H3K9me3 in A549 xenograft mouse model.
| M.Wt | 463.966 | |
| Formula | C25H26ClN5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Vougiouklakis T, et al. Oncotarget. 2018 Aug 7;9(61):31820-31831.
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