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NPD13668

Chemical Structure : NPD13668

CAS No.: 864819-54-5

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NPD13668 (NPD-13668;NPD 13668)

Catalog No.: PC-36041Not For Human Use, Lab Use Only.

NPD13668 (NPD-13668) is a chemical novel modulator of EZH2-mediated gene silencing, inhibits EZH2/PCR2 activity and decreases H3K27me3 levels.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    NPD13668 (NPD-13668) is a chemical novel modulator of EZH2-mediated gene silencing, inhibits EZH2/PCR2 activity and decreases H3K27me3 levels.
    NPD13668 reactivates the expression of silenced H3K27me3 target genes together with depletion of the H3K27me3 modification.
    NPD13668 effectively suppressed the cell growth of solid tumors even without EZH2 active mutations.
    NPD13668 inhibits cell proliferation in many cancer cells (PC3 cell IC50=5.39 uM).
    NPD13668 is a potential modulator of EZH2 methyltransferase activity.

    Physicochemical Properties

    M.Wt 392.411
    Formula C22H20N2O5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(2-(1H-indol-3-yl)ethyl)-2-(7,8-dihydroxy-4-methyl-2-oxo-2H-chromen-3-yl)acetamide

    References

    1. Murashima A, et al. J Biochem. 2019 Jan 25. doi: 10.1093/jb/mvz007.

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