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PJ-68

Chemical Structure : PJ-68

CAS No.: 352544-59-3

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PJ-68 (PJ68)

Catalog No.: PC-63229Not For Human Use, Lab Use Only.

PJ-68 is a potent, selective inhibitor of arginine methyltransferase PRMT5 with IC50 of 517 nM, shows no inhibitory activity against type I PRMT family members ( (PRMT1, 3, 4, 6, and 8).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

PJ-68 is a potent, selective inhibitor of arginine methyltransferase PRMT5 with IC50 of 517 nM, shows no inhibitory activity against type I PRMT family members ( (PRMT1, 3, 4, 6, and 8).
PJ-68 markedly decreases BCR-ABL mRNA levels in both CD34+CD38-cells and CD34+CD38+ cells, reduces survival and self-renewal capacity of CML CD34+ cells, increases p15INK4B and p27KIP1 but not p16INK4A and p57KIP2 expression.
PJ-68 reduces growth of CML LSCs and prolongs survival of CML mice.

Physicochemical Properties

M.Wt 354.497
Formula C25H26N2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-((9-ethyl-9H-carbazol-3-yl)methyl)-1,2,3,4-tetrahydronaphthalen-1-amine

References

1. Jin Y, et al. J Clin Invest. 2016 Oct 3;126(10):3961-3980.

2. Kaushik S, et al. Leukemia. 2018 Feb;32(2):499-509.

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