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Chemical Structure : G9a inhibitor E72
Catalog No.: PC-63022Not For Human Use, Lab Use Only.
G9a inhibitor E72 (E-72) is a potent inhibitor of histone H3K9 methyltransferases G9a and G9a-like protein (GLP) with Kd of 136 nM and 164 nM, shows selectivity over the related H3K9 methyltransferase Suv39H2.
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G9a inhibitor E72 (E72) is a potent inhibitor of histone H3K9 methyltransferases G9a and G9a-like protein (GLP) with Kd of 136 nM and 164 nM, shows selectivity over the related H3K9 methyltransferase Suv39H2.
G9a inhibitor E72 reactivates K-ras-mediated epigenetic silencing of the proapoptotic Fas gene in NIH 3T3 cells, with much reduced cell cytotoxicity compared with BIX-01294.
| M.Wt | 544.789 | |
| Formula | C29H52N8O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Chang Y, et al. J Mol Biol. 2010 Jul 2;400(1):1-7.
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