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G9a inhibitor E72

Chemical Structure : G9a inhibitor E72

CAS No.: 1435055-73-4

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G9a inhibitor E72 (E72)

Catalog No.: PC-63022Not For Human Use, Lab Use Only.

G9a inhibitor E72 (E-72) is a potent inhibitor of histone H3K9 methyltransferases G9a and G9a-like protein (GLP) with Kd of 136 nM and 164 nM, shows selectivity over the related H3K9 methyltransferase Suv39H2.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    G9a inhibitor E72 (E72) is a potent inhibitor of histone H3K9 methyltransferases G9a and G9a-like protein (GLP) with Kd of 136 nM and 164 nM, shows selectivity over the related H3K9 methyltransferase Suv39H2.
    G9a inhibitor E72 reactivates K-ras-mediated epigenetic silencing of the proapoptotic Fas gene in NIH 3T3 cells, with much reduced cell cytotoxicity compared with BIX-01294.

    Physicochemical Properties

    M.Wt 544.789
    Formula C29H52N8O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    7-((5-aminopentyl)oxy)-N4-(1-(5-aminopentyl)piperidin-4-yl)-N2-(3-(dimethylamino)propyl)-6-methoxyquinazoline-2,4-diamine

    References

    1. Chang Y, et al. J Mol Biol. 2010 Jul 2;400(1):1-7.

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