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Chemical Structure : CARM1-IN-7g
CAS No.: 1020399-49-8
Catalog No.: PC-43184Not For Human Use, Lab Use Only.
CARM1-IN-7g is a potent, selective coactivator-associated arginine methyltransferase 1 (CARM1) with IC50 of 8.6 uM, exhibits lower or no activity against a panel of different PRMTs or HKMTs (>80-fold over PRMT1 and SET7).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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CARM1-IN-7g is a potent, selective coactivator-associated arginine methyltransferase 1 (CARM1) with IC50 of 8.6 uM, exhibits lower or no activity against a panel of different PRMTs or HKMTs (>80-fold over PRMT1 and SET7).
CARM1-IN-7g inhibits CARM1-mediated methylation of different substrates (PABP1, CA150, SmB, and H3) up to single-digit micromolar level, significantly and dose-dependently reduces the prostate-specific antigen (PSA) promoter activity in human prostate cancer LNCaP cells, does not affect cell viability.
| M.Wt | 555.2578 | |
| Formula | C26H21Br2NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 35 mg/mL |
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| Chemical Name/SMILES |
4-Piperidinone, 3,5-bis[(3-bromo-4-hydroxyphenyl)methylene]-1-(phenylmethyl)- |
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1. Cheng D, et al. J Med Chem. 2011 Jul 14;54(13):4928-32.
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