Catalog No.: PC-43165Not For Human Use, Lab Use Only.
EPZ015666 (GSK3235025) is a potent, selective, orally available inhibitor of PRMT5 with Ki/IC50 of 5/22 nM, displays broad selectivity against a panel of other histone methyltransferases.
EPZ015666 (GSK3235025) is a potent, selective, orally available inhibitor of PRMT5 with Ki/IC50 of 5/22 nM, displays broad selectivity against a panel of other histone methyltransferases.
EPZ015666 (GSK3235025) inhibits SmD3 methylation and causes cell death in MCL cell lines (IC50=61-904 nM).
EPZ015666 (GSK3235025) demonstrates potent concentration-dependent antiproliferative effects against Z-138 and Maver-1 cells with IC50 of 96 and 450 nM, respectively.
EPZ015666 (GSK3235025) exhibits antitumor activity in multiple MCL xenograft models.
