Chemical Structure : UNC0379 trifluoroacetate
CAS No.:
1620401-83-3
UNC0379 trifluoroacetate
(UNC-0379 trifluoroacetate)
Catalog No. : PC-42984Not For Human Use, Lab Use Only.
UNC0379 trifluoroacetate is a selective, substrate-competitive inhibitor of lysine methyltransferase SETD8 with IC50 of 7.3 uM.
Packing Price Stock Quantity 5 mg $98 In stock 0 1 2 3 4 5 25 mg $258 In stock 0 1 2 3 4 5 50 mg $398 In stock 0 1 2 3 4 5 100 mg $628 In stock 0 1 2 3 4 5 200 mg Get quote 0 1 2 3 4 5 1 g Get quote 0 1 2 3 4 5
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-4298401
Biological Activity
UNC0379 trifluoroacetate is a selective, substrate-competitive inhibitor of lysine methyltransferase SETD8 with IC50 of 7.3 uM, displays good selectivity over 15 other methyltransferases, including G9a and GLP (IC50>100 uM).
Physicochemical Properties
M.Wt
527.5797
Formula
C25H36F3N5O4
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
4-Quinazolinamine, 6,7-dimethoxy-2-(1-pyrrolidinyl)-N-[5-(1-pyrrolidinyl)pentyl]-, 2,2,2-trifluoroacetate (1:x)
References
1. Ma A, et al. J Med Chem.
2. Ma A, et al. Medchemcomm.
3. Veschi V, et al. Cancer Cell.
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