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Chemical Structure : UNC0379 trifluoroacetate
CAS No.: 1620401-83-3
Catalog No.: PC-42984Not For Human Use, Lab Use Only.
UNC0379 trifluoroacetate is a selective, substrate-competitive inhibitor of lysine methyltransferase SETD8 with IC50 of 7.3 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | $628 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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UNC0379 trifluoroacetate is a selective, substrate-competitive inhibitor of lysine methyltransferase SETD8 with IC50 of 7.3 uM, displays good selectivity over 15 other methyltransferases, including G9a and GLP (IC50>100 uM).
UNC0379 causes neuroblastoma (NB) cell growth inhibition which is p53 dependent.
UNC0379 reduces levels of p53K382me1 modification in xenografts.
| M.Wt | 527.5797 | |
| Formula | C25H36F3N5O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-Quinazolinamine, 6,7-dimethoxy-2-(1-pyrrolidinyl)-N-[5-(1-pyrrolidinyl)pentyl]-, 2,2,2-trifluoroacetate (1:x) |
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1. Ma A, et al. J Med Chem. 2014 Aug 14;57(15):6822-33.
2. Ma A, et al. Medchemcomm. 2014 Dec;5(12):1892-1898.
3. Veschi V, et al. Cancer Cell. 2017 Jan 9;31(1):50-63.
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