You are here:Home-Chemical Inhibitors & Agonists-Epigenetics-Histone Methyltransferase (HMTase)-UNC0379
UNC0379

Chemical Structure : UNC0379

CAS No.: 1620401-82-2

UNC0379 (UNC 0379, UNC-0379)

Catalog No.: PC-42983Not For Human Use, Lab Use Only.

UNC0379 is a selective, substrate-competitive inhibitor of lysine methyltransferase SETD8 with IC50 of 7.3 uM.

Packing Price Stock Quantity
10 mg $88 In stock
25 mg $138 In stock
50 mg $218 In stock
100 mg $358 In stock
250 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

UNC0379 is a selective, substrate-competitive inhibitor of lysine methyltransferase SETD8 with IC50 of 7.3 uM.
UNC0379 displays good selectivity over 15 other methyltransferases, including G9a and GLP (IC50>100 uM).
UNC0379 causes neuroblastoma (NB) cell growth inhibition which is p53 dependent, reduces levels of p53K382me1 modification in xenografts.

Physicochemical Properties

M.Wt 413.5563
Formula C23H35N5O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-Quinazolinamine, 6,7-dimethoxy-2-(1-pyrrolidinyl)-N-[5-(1-pyrrolidinyl)pentyl]-

References

1. Ma A, et al. J Med Chem. 2014 Aug 14;57(15):6822-33.

2. Ma A, et al. Medchemcomm. 2014 Dec;5(12):1892-1898.

3. Veschi V, et al. Cancer Cell. 2017 Jan 9;31(1):50-63.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: