NSD3 inhibitor A8

Chemical Structure : NSD3 inhibitor A8

Catalog No.: PC-24327Not For Human Use, Lab Use Only.

NSD3 inhibitor A8 is a potent small molecule inhibitor of nuclear receptor-binding SET domain protein 3 (NSD3) with IC50 of 0.7 uM, inhibits NSD1 and NSD2 with IC50 of 1.5 uM and 0.9 uM respectively.

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Biological Activity

NSD3 inhibitor A8 is a potent small molecule inhibitor of nuclear receptor-binding SET domain protein 3 (NSD3) with IC50 of 0.7 uM, inhibits NSD1 and NSD2 with IC50 of 1.5 uM and 0.9 uM respectively.
NSD3 inhibitor A8 inhibits LUSC cell proliferation, with an IC50 of 0.355 μM in NCI-H1703 cells, and less toxicity to non-cancerous HEK293T cells.
NSD3 inhibitor A8 exhibits inhibitory effects on LUSC cells in vitro and tumors in mice in vivo.

Physicochemical Properties

M.Wt	330.74
Formula	C17H12ClFN2O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-chloro-7-((3-fluorophenethyl)amino)quinoline-5,8-dione

References

1. Xiu S, et al. Eur J Med Chem. 2025 May 5;289:117388.

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