Chemical Structure : CM112
CAS No.:
CM112
Catalog No.: PC-24375Not For Human Use, Lab Use Only.
CM112 is a potent, selective PRMT1 degrader designed by tethering adamantane to MS023 via a 5-PEG linker, has DC50 of 0.83 uM in MCF-7 cells.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
CM112 is a potent, selective PRMT1 degrader designed by tethering adamantane to MS023 via a 5-PEG linker, has DC50 of 0.83 uM in MCF-7 cells.
CM112 reduces PRMT1 level in a time-dependent manner.
Cotreatment with the proteasome inhibitor MG132 (0.1 μM or 1 μM) and CM112 (10 μM) effectively prevent the degradation of PRMT1 in MCF-7 cells, aligning with the proteasome-dependent mechanism of HyTDs.
CM112 induces the degradation of post-translational PRMT1 without impairing the processes of genetic transcription and translation.
CM112 is still a potent type I PRMTs (PRMT1/3/4/6) pan inhibitor with IC50 values ranging from 9 nM to 224 nM.
CM112 does not affect protein level of PRMT3/4/6.
CM112 suppressed the proliferation of MCF-7 and MDA-MB-231 cells.
CM112 reduces the stability of orphan receptor TR3, which is a binding partner of PRMT1.
Physicochemical Properties
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M.Wt
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711.95
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Formula
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C39H61N5O7
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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1-(2-((3r,5r, 7r)-adamantan-1-yl)acetamido)-N-(4-(4-(((2-aminoethyl) (methyl)amino)methyl)-1H-pyrrol-3-yl)phenyl)-3,6,9,12,15-pentaoxaoctadecan-18-amide
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References
1. Ma C, et al. Eur J Med Chem. 2025 Apr 14;291:117625.
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