Chemical Structure : Dual CARM1-IKZF3 inhibitor 074
CAS No.:
Dual CARM1-IKZF3 inhibitor 074
Catalog No.: PC-24292Not For Human Use, Lab Use Only.
Dual CARM1-IKZF3 inhibitor 074 is a compound composed of the CARM1 inhibitor EZM2302, linked to pomalidomide, increases CRBN-dependent IKZF1, IKZF3, ZFP91, and FGD3 protein degradation, inhibits CRAM1 with IC50 of 2 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Dual CARM1-IKZF3 inhibitor 074 is a compound composed of the CARM1 inhibitor EZM2302, linked to pomalidomide, increases CRBN-dependent IKZF1, IKZF3, ZFP91, and FGD3 protein degradation, inhibits CRAM1 with IC50 of 2 nM.
074 more potently suppressed the growth of H929 cells than the combination of EZM2302 and pomalidomide.
074 074 can potently and selectively kill IMiD-resistant MM cells.
074 downregulated IKZF3, IKZF1, and MYC more potently than pomalidomide or EZM2302.
074 was able to override IMiD resistance.
Physicochemical Properties
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M.Wt
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896.44
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Formula
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C46H54ClN9O8
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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4-((6-(2-(2-(2-chloro-5-((R)-2-hydroxy-3-(methylamino)propoxy)phenyl)-6-(3,5-dimethylisoxazol-4-yl)-5-methylpyrimidin-4-yl)-2,7-diazaspiro[3.5]nonan-7-yl)-6-oxohexyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
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References
1. Ni W, et al. Mol Ther Oncol. 2025 Feb 20;33(1):200952.
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