iZMYND8-34

Chemical Structure : iZMYND8-34

Catalog No.: PC-24337Not For Human Use, Lab Use Only.

iZMYND8-34 is a small molecule inhibitor of histone reader zinc finger MYND-type containing 8 (ZMYND8), inhibits ZMYND8 histone recognition, effectively blocks neuroendocrine prostate cancer (NEPC) development.

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Biological Activity

iZMYND8-34 is a small molecule inhibitor of histone reader zinc finger MYND-type containing 8 (ZMYND8) with IC50 of 0.66 uM, inhibits ZMYND8 histone recognition, effectively blocks neuroendocrine prostate cancer (NEPC) development.

Physicochemical Properties

M.Wt	449.42
Formula	C22H19N5O6
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	9-(benzo[d][1,3]dioxol-5-yl)-2-(3-ethoxy-2-hydroxyphenyl)-7-methyl-8-oxo-8,9-dihydro-7H-purine-6-carboxamide

References

1. Wang H, et al. Nat Cancer. 2025 Mar 18. doi: 10.1038/s43018-025-00928-z.

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iZMYND8-34

Biological Activity

Physicochemical Properties

References

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