Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.

You are here:Home-Chemical Inhibitors & Agonists-Epigenetics-Histone Methyltransferase (HMTase)-DC-PRC2in-01
DC-PRC2in-01

Chemical Structure : DC-PRC2in-01

CAS No.: 120430-77-5

DC-PRC2in-01 (EZH2-EED inhibitor)

Catalog No.: PC-20124Not For Human Use, Lab Use Only.

DC-PRC2in-01 is a small molecule PRC2 inhibitor targeting EZH2-EED interaction with affinity Kd of 4.56 uM, decreases global H3K27me3 levels in cancer cells.

Packing Price Stock Quantity
50 mg Get quote
100 mg Get quote
250 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    DC-PRC2in-01 is a small molecule PRC2 inhibitor targeting EZH2-EED interaction with affinity Kd of 4.56 uM, decreases global H3K27me3 levels in cancer cells.
    DC-PRC2in-01 shows an IC50 of 4.21 μM for bindingt to EED in the fluorescence polarization (FP) competitive binding assays.
    DC-PRC2in-01 destabilizes the PRC2 complex, thereby leading to the degradation of PRC2 core proteins and the decrease of global H3K27me3 levels in cancer cells.
    DC-PRC2in-01 effectively inhibits the proliferation of PRC2-driven lymphomas cells, arrested the cell cycle in the G0/G1 phase.
    DC-PRC2in-01 shows growth inhibition effects on cancer cells, including Pfeiffer, KARPAS422, SU-DHL-4, and DB, via a cell viability assay (IC50s=3.5-10 uM).

    Physicochemical Properties

    M.Wt 444.55
    Formula C27H29FN4O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    1-(4-fluorobenzyl)-N-(1-(4-methoxyphenethyl)pyrrolidin-3-yl)-1H-benzo[d]imidazol-2-amine

    References

    1. Daohai Du, et al. J Med Chem. 2021 Jun 24;64(12):8194-8207.

    Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    Contact Us sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    Get Quote

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • Additional Information: