Chemical Structure : MS1262
CAS No.:
MS1262
(MS 1262)
Catalog No.: PC-21346Not For Human Use, Lab Use Only.
MS1262 is a highly potent, selective and brain-penetrant inhibitor of G9a/GLP methylase with IC50 of 19/6 nM, respectively.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
MS1262 is a highly potent, selective and brain-penetrant inhibitor of G9a/GLP methylase with IC50 of 19/6 nM, respectively.
MS1262 shows 23-fold and 37-fold higher potency than UNC0642.
MS1262 shows high binding affinities to G9a (Kd = 74 ± 10 nM) and GLP (Kd = 19 ± 5 nM) in isothermal titration calorimetry (ITC) assays.
MS1262 displays excellent selectivity for G9a and GLP over any of the 21 other methyltransferases tested.
MS1262 effectively reduces histone H3 lysine 9 dimethylation in cells in a concentrationdependent manner.
MS1262 restores both cognitive and noncognitive functions to healthy levels in multiple Alzheimer's disease (AD) mouse models.
Physicochemical Properties
|
M.Wt
|
511.71
|
|
Formula
|
C29H45N5O3
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
N-(1-isopropylpiperidin-4-yl)-6-methoxy-2-morpholino-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-amine
|
References
1. Xie L, et al. medRxiv. 2023 Oct 26:2023.10.25.23297491.
Contact Us
sales@probechem.com
