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MS1262

Chemical Structure : MS1262

CAS No.:

MS1262 (MS 1262)

Catalog No.: PC-21346Not For Human Use, Lab Use Only.

MS1262 is a highly potent, selective and brain-penetrant inhibitor of G9a/GLP methylase with IC50 of 19/6 nM, respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

MS1262 is a highly potent, selective and brain-penetrant inhibitor of G9a/GLP methylase with IC50 of 19/6 nM, respectively.
MS1262 shows 23-fold and 37-fold higher potency than UNC0642.
MS1262 shows high binding affinities to G9a (Kd = 74 ± 10 nM) and GLP (Kd = 19 ± 5 nM) in isothermal titration calorimetry (ITC) assays.
MS1262 displays excellent selectivity for G9a and GLP over any of the 21 other methyltransferases tested.
MS1262 effectively reduces histone H3 lysine 9 dimethylation in cells in a concentrationdependent manner.
MS1262 restores both cognitive and noncognitive functions to healthy levels in multiple Alzheimer's disease (AD) mouse models.

Physicochemical Properties

M.Wt 511.71
Formula C29H45N5O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(1-isopropylpiperidin-4-yl)-6-methoxy-2-morpholino-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-amine

References

1. Xie L, et al. medRxiv. 2023 Oct 26:2023.10.25.23297491.

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