METTL3 inhibitor 54

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Chemical Structure : METTL3 inhibitor 54

Catalog No.: PC-21078Not For Human Use, Lab Use Only.

METTL3 inhibitor 54 is a potent, selective inhibitor of m6A-RNA writer enzyme methyltransferase-like 3 (METTL3) with IC50 of 54 nM for METTL3/METTL14 in HTRF assays.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

METTL3 inhibitor 54 is a potent, selective inhibitor of m6A-RNA writer enzyme methyltransferase-like 3 (METTL3) with IC50 of 54 nM for METTL3/METTL14 in HTRF assays.
METTL3 inhibitor 54 displays no activity against METTL1 and METTL16 up to 200 μM.
METTL3 inhibitor 54 shows a GI50 of 6 μM for the MOLM-13 AML cell line.

Physicochemical Properties

M.Wt	590.82
Formula	C37H46N6O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	OC1(CNC2=C3C=CC(CN4C(C(C)C)C5(CCC5)C4)=CC3=CC=C2)CN(C6=NC=NC(NCC7=CC=CC=C7)=C6)CCC1

References

1. Bedi RK, et al. ACS Bio Med Chem Au. 2023 Jun 14;3(4):359-370.

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