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Chemical Structure : NSUN2 inhibitor MY-1B
CAS No.: 2929308-79-0
Catalog No.: PC-21301Not For Human Use, Lab Use Only.
NSUN2 inhibitor MY-1B is specific, covalent inhibitor of RNA methyltransferase NSUN2 (IC50=1.3 uM) that stereoselectively react with the catalytic C271, has IC50 of 2.4 uM in RNA methylation assays.
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NSUN2 inhibitor MY-1B is specific, covalent inhibitor of RNA methyltransferase NSUN2 (IC50=1.3 uM) that stereoselectively react with the catalytic C271, has IC50 of 2.4 uM in RNA methylation assays.
MY-1B do not cross-react with other human NSUNs.
MY-1B shows IC50 values for effects on cell growth that ranged from10-30 uM in human cancer cell lines treated with theazetidine acrylamides for 48 h.
MY-1B suppresses NSUN2-tRNA interactions in human cells.
| M.Wt | 436.31 | |
| Formula | C22H18BrN3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(2R,3S)-1-acryloyl-3-(4-bromophenyl)-N-(quinolin-8-yl)azetidine-2-carboxamide |
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1. Tao Y, et al. Angew Chem Int Ed Engl. 2023 Nov 1:e202311924.
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