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EML734

Chemical Structure : EML734

CAS No.:

EML734 (EML-734)

Catalog No.: PC-21012Not For Human Use, Lab Use Only.

EML734 is a selective small molecule inhibitor of protein arginine methyltransferase isoforms, PRMT7 and PRMT9 with IC50 of 0.32 and 0.89 uM, respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

EML734 is a selective small molecule inhibitor of protein arginine methyltransferase isoforms, PRMT7 and PRMT9 with IC50 of 0.32 and 0.89 uM, respectively.
EML734 dispaly little to no activity against other PRMTs.
EML734 affects PRMT activity even in a cellular context.

Physicochemical Properties

M.Wt 608.62
Formula C27H32N10O7
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

O=C(OC)C1=CC(O)=C2C=C(NC(NCCCNC(NC[C@H]3O[C@@H](N4C=NC5=C(N)N=CN=C45)[C@H](O)[C@@H]3O)=N)=O)C=CC2=C1

References

1. Alessandra Feoli, et al. J Med Chem. 2023 Aug 10. doi: 10.1021/acs.jmedchem.3c01030.

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