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EML734

Chemical Structure : EML734

CAS No.: 3031795-11-3

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EML734 (EML-734)

Catalog No.: PC-21012Not For Human Use, Lab Use Only.

EML734 is a selective small molecule inhibitor of protein arginine methyltransferase isoforms, PRMT7 and PRMT9 with IC50 of 0.32 and 0.89 uM, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    EML734 is a selective small molecule inhibitor of protein arginine methyltransferase isoforms, PRMT7 and PRMT9 with IC50 of 0.32 and 0.89 uM, respectively.
    EML734 dispaly little to no activity against other PRMTs.
    EML734 affects PRMT activity even in a cellular context.

    Physicochemical Properties

    M.Wt 608.62
    Formula C27H32N10O7
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    methyl 6-(3-(3-(3-(((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)guanidino)propyl)ureido)-4-hydroxy-2-naphthoate

    References

    1. Alessandra Feoli, et al. J Med Chem. 2023 Aug 10. doi: 10.1021/acs.jmedchem.3c01030.

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