You are here:Home-Chemical Inhibitors & Agonists-Epigenetics-Histone Methyltransferase (HMTase)-3-Deazaneplanocin A
3-Deazaneplanocin A

Chemical Structure : 3-Deazaneplanocin A

CAS No.: 102052-95-9

3-Deazaneplanocin A (NSC 617989, 3-Deazaneplanocin, DZNep)

Catalog No.: PC-42587Not For Human Use, Lab Use Only.

3-Deazaneplanocin A (DZNep) is a highly potent and competitive S-adenosylhomocysteine hydrolase inhibitor with Ki of 0.05 nM, also inhibits histone methyltransferase EZH2.

Packing Price Stock Quantity
1 mg $128 In stock
5 mg $258 In stock
10 mg Get quote
25 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

3-Deazaneplanocin A (DZNep) is a highly potent and competitive S-adenosylhomocysteine hydrolase inhibitor with Ki of 0.05 nM, also inhibits histone methyltransferase EZH2.
3-Deazaneplanocin A (DZNep) is more potent than 3-deazaaristeromycin.
3-Deazaneplanocin A (DZNep) induces EZH2 protein depletion, leads to cell death in several cancers and tumors; anticancer or antiviral agent.

Physicochemical Properties

M.Wt 262.2646
Formula C12H14N4O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-Cyclopentene-1,2-diol, 5-(4-amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-, (1S,2R,5R)-

References

1. Tseng CK, et al. J Med Chem. 1989 Jul;32(7):1442-6.

2. Glazer RI, et al. Biochem Biophys Res Commun. 1986 Mar 13;135(2):688-94.

3. Fiskus W, et al. Blood. 2009 Sep 24;114(13):2733-43.

4. Puppe J, et al. Breast Cancer Res. 2009;11(4):R63.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: