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Chemical Structure : HLCL-61 hydrochloride
CAS No.: 1158279-20-9
Catalog No.: PC-42037Not For Human Use, Lab Use Only.
HLCL-61 hydrochloride is a potent and selective protein arginine methyltransferase PRMT5 inhibitor.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $78 | In stock | |
| 25 mg | $118 | In stock | |
| 50 mg | $188 | In stock | |
| 100 mg | Get quote |
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HLCL-61 hydrochloride is a potent and selective protein arginine methyltransferase PRMT5 inhibitor.
HLCL-61 shows no inhibitory activity against the type I (PRMT1 and PRMT4) and type II (PRMT7) PRMT family members.
HLCL-61 exhibits effective inhibition of symmetric arginine dimethylation (me2) of histones H3 and H4 in AML samples, significantly increases expression of miR-29b and consequent suppression of Sp1 and FLT3 in AML cells.
HLCL-61 inhibits the proliferation of AML cell lines and primary blasts with IC50 of 7.21-21.46 uM.
| M.Wt | 380.9104 | |
| Formula | C23H25ClN2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 30 mg/mL |
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| Chemical Name/SMILES |
9H-Carbazole-3-methanamine, 9-ethyl-N-[(2-methoxyphenyl)methyl]-, hydrochloride (1:1) |
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1. Tarighat SS, et al. Leukemia. 2016 Apr;30(4):789-99.
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