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Chemical Structure : UNC0321
CAS No.: 1238673-32-9
Catalog No.: PC-42741Not For Human Use, Lab Use Only.
UNC0321 (UNC-0321) is a highly potent, selective histone methyltransferase G9a inhibitor with Ki of 63 pM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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UNC0321 (UNC-0321) is a highly potent, selective histone methyltransferase G9a inhibitor with Ki of 63 pM.
UNC0321 inhibits G9a and GLP with IC50 of 6 nM and 23 nM in CLOT biochemical assays.
UNC0321 dispalys >1000-fold selectivity for G9a over SET7/9, SET8, PRMT3 and JMJD2E (IC50>4 uM); but lacks sufficient cellular potency.
| M.Wt | 515.6913 | |
| Formula | C27H45N7O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 31 mg/mL |
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| Chemical Name/SMILES |
4-Quinazolinamine, 7-[2-[2-(dimethylamino)ethoxy]ethoxy]-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N-(1-methyl-4-piperidinyl)- |
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1. Liu F, et al. J Med Chem. 2010 Aug 12;53(15):5844-57.
2. Liu F, et al. J Med Chem. 2011 Sep 8;54(17):6139-50.
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