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Chemical Structure : 3-Deazaneplanocin A hydrochloride
CAS No.: 120964-45-6
Catalog No.: PC-42907Not For Human Use, Lab Use Only.
3-Deazaneplanocin A (DZNep) hydrochloride is a highly potent and competitive S-adenosylhomocysteine hydrolase inhibitor with Ki of 0.05 nM, also inhibits histone methyltransferase EZH2.
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3-Deazaneplanocin A (DZNep) hydrochloride is a highly potent and competitive S-adenosylhomocysteine hydrolase inhibitor with Ki of 0.05 nM, also inhibits histone methyltransferase EZH2.
3-Deazaneplanocin A (DZNep) is more potent than 3-deazaaristeromycin.
3-Deazaneplanocin A (DZNep) induces EZH2 protein depletion, leads to cell death in several cancers and tumors; anticancer or antiviral agent.
| M.Wt | 298.7255 | |
| Formula | C12H15ClN4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-Cyclopentene-1,2-diol, 5-(4-amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-, hydrochloride (1:1), (1S,2R,5R)- |
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1. Tseng CK, et al. J Med Chem. 1989 Jul;32(7):1442-6.
2. Glazer RI, et al. Biochem Biophys Res Commun. 1986 Mar 13;135(2):688-94.
3. Fiskus W, et al. Blood. 2009 Sep 24;114(13):2733-43.
4. Puppe J, et al. Breast Cancer Res. 2009;11(4):R63.
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