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Chemical Structure : A-196
CAS No.: 1982372-88-2
Catalog No.: PC-42081Not For Human Use, Lab Use Only.
A-196 is a potent, selective and substrate-competitive inhibitor of protein lysine methyltransferases (PKMTs) SUV420H1 and SUV420H2 with IC50 of 25 nM and 144 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $318 | In stock | |
| 50 mg | $528 | In stock | |
| 100 mg | Get quote |
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A-196 is a potent, selective and substrate-competitive inhibitor of protein lysine methyltransferases (PKMTs) SUV420H1 and SUV420H2 with IC50 of 25 nM and 144 nM, respectively.
A-196 shows no activity for other PKMTs including PR-SET7, and PRMTs, DNMTases.
A-196 induces a global decrease in H4K20me2 and H4K20me3 (EC50= 262 and 370 nM, respectively) and a concomitant increase in H4K20me1 (EC50=735 nM) in U2OS cells, inhibits 53BP1 foci formation upon ionizing radiation and reduces NHEJ-mediated DNA-break repair but does not affect homology-directed repair.
| M.Wt | 359.2524 | |
| Formula | C18H16Cl2N4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 31 mg/mL |
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| Chemical Name/SMILES |
6,7-dichloro-N-cyclopentyl-4-(pyridin-4-yl)phthalazin-1-amine |
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1. Bromberg KD, et al. Nat Chem Biol. 2017 Mar;13(3):317-324.
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