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UNC3866

Chemical Structure : UNC3866

CAS No.: 1872382-47-2

UNC3866 (UNC 3866, UNC-3866)

Catalog No.: PC-42272Not For Human Use, Lab Use Only.

UNC3866 is a potent, selective PRC1 chromodomains antagonist that binds to CBX4 and CBX7 with Kd of 100 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

UNC3866 is a potent, selective PRC1 chromodomains antagonist that binds to CBX4 and CBX7 with Kd of 100 nM.
UNC3866 displays 6- to 18-fold selectivity versus other CBX (CBX2/6/8) and CDY chromodomains, highly selectivity versus >250 other taergets in a Kme reader panel.
UNC3866 inhibits PC3 cell proliferation with EC50 of 340 nM.

Physicochemical Properties

M.Wt 795.0195
Formula C43H66N6O8
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 27 mg/mL

Chemical Name/SMILES

L-Serine, N-[4-(1,1-dimethylethyl)benzoyl]-L-phenylalanyl-L-alanyl-L-leucyl-N6,N6-diethyl-L-lysyl-, methyl ester

References

1. Stuckey JI, et al. Nat Chem Biol. 2016 Mar;12(3):180-7.

2. Barnash KD, et al. ACS Chem Biol. 2016 Sep 16;11(9):2475-83.

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