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Chemical Structure : UNC3866
CAS No.: 1872382-47-2
Catalog No.: PC-42272Not For Human Use, Lab Use Only.
UNC3866 is a potent, selective PRC1 chromodomains antagonist that binds to CBX4 and CBX7 with Kd of 100 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $138 | In stock | |
| 25 mg | $228 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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UNC3866 is a potent, selective PRC1 chromodomains antagonist that binds to CBX4 and CBX7 with Kd of 100 nM.
UNC3866 displays 6- to 18-fold selectivity versus other CBX (CBX2/6/8) and CDY chromodomains, highly selectivity versus >250 other taergets in a Kme reader panel.
UNC3866 inhibits PC3 cell proliferation with EC50 of 340 nM.
| M.Wt | 795.0195 | |
| Formula | C43H66N6O8 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 27 mg/mL |
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| Chemical Name/SMILES |
L-Serine, N-[4-(1,1-dimethylethyl)benzoyl]-L-phenylalanyl-L-alanyl-L-leucyl-N6,N6-diethyl-L-lysyl-, methyl ester |
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1. Stuckey JI, et al. Nat Chem Biol. 2016 Mar;12(3):180-7.
2. Barnash KD, et al. ACS Chem Biol. 2016 Sep 16;11(9):2475-83.
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