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Chemical Structure : MI-503
CAS No.: 1857417-13-0
Catalog No.: PC-45092Not For Human Use, Lab Use Only.
MI-503 (MI 503) is a highly potent and orally bioavailable small-molecule inhibitor of Menin-MLL interaction with Kd of 9.3 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $118 | In stock | |
| 10 mg | $178 | In stock | |
| 25 mg | $288 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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MI-503 (MI 503) is a highly potent and orally bioavailable small-molecule inhibitor of Menin-MLL interaction with Kd of 9.3 nM.
MI-503 effectively induces differentiation of MLL leukemia cells and and substantially increases expression of CD11b, also reduces expression of Hoxa9 and Meis1.
MI-503 induces marked anti-proliferative effects in MV4;11 cells with GI50 of 200 nM.
MI-503 blocks hematologic tumors in vivo and reduces MLL leukemia tumor burden in mouse models.
| M.Wt | 564.6278 | |
| Formula | C28H27F3N8S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-((1H-pyrazol-4-yl)methyl)-4-methyl-5-((4-((6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)methyl)-1H-indole-2-carbonitrile |
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1. Borkin D, et al. Cancer Cell. 2015 Apr 13;27(4):589-602.
2. Svoboda LK, et al. Oncotarget. 2017 Jan 3;8(1):458-471.
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