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MI-136

Chemical Structure : MI-136

CAS No.: 1628316-74-4

MI-136 (MI 136;MI136)

Catalog No.: PC-45602Not For Human Use, Lab Use Only.

MI-136 is a potent Menin-MLL interaction inhibitor with IC50 of 31 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

MI-136 is a potent Menin-MLL interaction inhibitor with IC50 of 31 nM.
MI-136 demonstrates potent inhibitory activity and strong binding affinity to menin.

Physicochemical Properties

M.Wt 470.5132
Formula C23H21F3N6S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 31 mg/mL

Chemical Name/SMILES

1H-Indole-2-carbonitrile, 5-[[4-[[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]-1-piperidinyl]methyl]-

References

1. Borkin D, et al. J Med Chem. 2016 Feb 11;59(3):892-913.

2. Borkin D, et al. Cancer Cell. 2015 Apr 13;27(4):589-602.

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