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Chemical Structure : LLY-507
CAS No.: 1793053-37-8
Catalog No.: PC-45598Not For Human Use, Lab Use Only.
LLY-507 is a potent, selective and cell-active inhibitor of SMYD2 (IC50<15 nM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote |
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LLY-507 is a potent, selective and cell-active inhibitor of SMYD2 (IC50<15 nM).
LLY-507 displays >100-fold selective over a broad range of methyltransferase and non-methyltransferase targets.
LLY-507 inhibits SMYD2-mediated methylation of p53 Lys370 and suppresses proliferation of several esophageal, liver, and breast cancer cell lines in a dose-dependent manner (IC50=1.5-6 uM).
| M.Wt | 574.7583 | |
| Formula | C36H42N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 15 mg/mL |
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| Chemical Name/SMILES |
[1,1'-Biphenyl]-3-carboxamide, 5-cyano-2'-[4-[2-(3-methyl-1H-indol-1-yl)ethyl]-1-piperazinyl]-N-[3-(1-pyrrolidinyl)propyl]- |
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1. Nguyen H, et al. J Biol Chem. 2015 May 29;290(22):13641-53.
2. Olsen JB, et al. Mol Cell Proteomics. 2016 Mar;15(3):892-905.
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