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Chemical Structure : UM171
CAS No.: 1448724-09-1
Catalog No.: PC-62316Not For Human Use, Lab Use Only.
UM171 (UM-171) is a potent agonist of human hematopoietic stem cell (HSC) self-renewal, shows 10 to 20 times more potent than UM729 with effective concentrations of 17 to 19 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $488 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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UM171 (UM-171) is a potent agonist of human hematopoietic stem cell (HSC) self-renewal, shows 10 to 20 times more potent than UM729 with effective concentrations of 17 to 19 nM.
UM171 modulates the CoREST complex and causes LSD1 degradation, potentiates the activity of a CULLIN3-E3 ubiquitin ligase (CRL3) complex.
UM171 triggers Cul3-KBTBD4-mediated degradation of ELM2 domain-harboring proteins.
UM171 (UM-171) enables a robust ex vivo expansion of human CB cells with functionally validated long-term in vivo repopulating capability.
| M.Wt | 487.94 | |
| Formula | C25H27N9 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(1r,4r)-N1-(2-benzyl-7-(2-methyl-2H-tetrazol-5-yl)-9H-pyrimido[4,5-b]indol-4-yl)cyclohexane-1,4-diamine |
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1. Fares I, et al. Science. 2014 Sep 19;345(6203):1509-12.
2. Li X, et al. Stem Cell Res. 2017 May;21:32-39.
3. Zonari E, et al. Stem Cell Reports. 2017 Apr 11;8(4):977-990.
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