ML399 |CAS:1560968-49-1 Probechem Biochemicals

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Chemical Structure : ML399

ML399 (VU0516340)

Catalog No.: PC-62142Not For Human Use, Lab Use Only.

ML399 (VU0516340) is a potent and cell penetrant menin-MLL inhibitor with IC50 of 90 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ML399 (VU0516340) is a potent and cell penetrant menin-MLL inhibitor with IC50 of 90 nM.
ML399 (VU0516340) shows improved potency and DMPK properties.
ML399 (VU0516340) is a chemical probe for in vivo proof-of-mechanism studies.

Physicochemical Properties

M.Wt	445.538
Formula	C27H28FN3O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-4-(3-(4-((3-Fluorophenyl)(hydroxy)(pyridin-2-yl)methyl)piperidin-1-yl)propoxy)benzonitrile

References

1. Senter T, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].

2. Senter T, et al. Bioorg Med Chem Lett. 2015 Jul 1;25(13):2720-5.

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ML399 (VU0516340)

Biological Activity

Physicochemical Properties

References

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