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UNC-2170

Chemical Structure : UNC-2170

CAS No.: 1648707-58-7

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UNC-2170 (UNC2170)

Catalog No.: PC-62384Not For Human Use, Lab Use Only.

UNC-2170 is a small molecule ligand for the methyl-lysine binding protein 53BP1 (p53-binding protein 1) with Kd of 22 uM against the 53BP1 tandem tudor domain.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

UNC-2170 is a small molecule ligand for the methyl-lysine binding protein 53BP1 (p53-binding protein 1) with Kd of 22 uM against the 53BP1 tandem tudor domain.
UNC-2170 is highly cell permeant with no significant measureable cellular efflux.
UNC-2170 shows modestly potent, demonstrates at least 17-fold selectivity for 53BP1 as compared to nine other Kme reader proteins.

Physicochemical Properties

M.Wt 313.23
Formula C14H21BrN2O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-bromo-N-(3-(tert-butylamino)propyl)benzamide

References

1. Perfetti MT, et al. ACS Chem Biol. 2015 Apr 17;10(4):1072-81.

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