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Chemical Structure : Valemetostat
CAS No.: 1809336-39-7
Catalog No.: PC-61403Not For Human Use, Lab Use Only.
Valemetostat (DS-3201, DS3201) is a potent, selective, dual EZH1/EZH2 inhibitor with IC50 <10 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $178 | In stock | |
| 10 mg | $288 | In stock | |
| 25 mg | $458 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Valemetostat (DS-3201, DS3201) is a potent, selective, dual EZH1/EZH2 inhibitor with IC50 <10 nM.
Valemetostat (DS-3201, DS3201) significantly reducs ATL cell viability compared with the others inhibitors.
Valemetostat (DS-3201, DS3201) significantly reactivates the expression of the highly H3K27me3-accumulated EZH1/2 target genes in an ex vivo culture of primary ATL cells.
Valemetostat shows superior anti-growth effects compared with EZH2-selective inhibitor in malignant lymphoma cell lines.
| M.Wt | 488.025 | |
| Formula | C26H34ClN3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
100 mM in DMSO |
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| Chemical Name/SMILES |
(2R)-7-chloro-2-[trans-4-(dimethylamino)cyclohexyl]-N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-2,4-dimethyl-1,3-benzodioxole-5-carboxamide |
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1. Yamagishi M, et al. Cell Rep. 2019 Nov 19;29(8):2321-2337.e7.
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