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Chemical Structure : PR5-LL-CM01
CAS No.: 1005307-86-7
Catalog No.: PC-61791Not For Human Use, Lab Use Only.
PR5-LL-CM01 is a novel selective, small-molecule inhibitor of PRMT5 methyltransferase with IC50 of 7.5 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $118 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | $528 | In stock | |
| 100 mg | Get quote |
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PR5-LL-CM01 is a novel selective, small-molecule inhibitor of PRMT5 methyltransferase with IC50 of 7.5 uM.
PR5-LL-CM01 displays >10-fold selectivity over PRMT3, and no inhibitory activity over PRMT1/4/6/8.
PR5-LL-CM01 exhibits cell viability inhibition with IC50 of 2-4 uM in PDAC cells, IC50 of 10-11 uM in CRC cells, more potent than EPZ015666.
PR5-LL-CM01 significantly inhibits NF-κB activation in PDAC and CRC cells, and shows dramatic anti-tumor efficacy in vivo.
| M.Wt | 401.518 | |
| Formula | C23H27N7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N6-(2-(dimethylamino)ethyl)-N4-(3,4-dimethylphenyl)-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine |
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1. Prabhu L, et al. Oncotarget. 2017 Jun 20;8(25):39963-39977.
2. Muniyandi A, et al. Sci Rep. 2023 Jan 31;13(1):1747.
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