PRMT1 activator TR-07

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Chemical Structure : PRMT1 activator TR-07

Catalog No.: PC-28112Not For Human Use, Lab Use Only.

PRMT1 activator TR-07 is a selective, cell-active PRMT1 activator with EC50 of 208.3 uM, selectively enhances the catalytic activity of PRMT1 in vitro.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

PRMT1 activator TR-07 is a selective, cell-active PRMT1 activator with EC50 of 208.3 uM, selectively enhances the catalytic activity of PRMT1 in vitro.
TR-07 binds to the αY helix near the catalytic core of PRMT1.
TR-07 enhances the sensitivity to gemcitabine-induced apoptosis in PDAC tumor cells.
TR-07 enhances global ADMA levels in pancreatic tumor cells and augments PRMT1's apoptotic function in cell culture and mouse models.

Physicochemical Properties

M.Wt	335.41
Formula	C20H21N3O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-4-(((3-((dimethylamino)methyl)benzyl)amino)methylene)isoquinoline-1,3(2H,4H)-dione

References

1. Salehipour-Bavarsad S, et al. J Med Chem. 2026 Sep 10;69(17):20116-20137.

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